Purpose: To review how patient-reported outcome (PRO) measures in mental health clinical research complement traditional clinician-rated outcome (CRO) measures.
Data sources: Medline, Embase, PsycInfo and Scopus.
Study selection: Latest update of the literature search was conducted in August 2019, using a specified set of search terms to identify controlled and uncontrolled studies (published since 1996) of pharmacological or non-pharmacological interventions in adults (≥18 years) in hospital-based mental health care.
Data extraction: Two authors extracted data independently using a pre-designed extraction form.
Results of data synthesis: Among the 2962 publications identified, 257 were assessed by full text reading. A total of 24 studies reported in 26 publications were included in this descriptive review. We identified subjective and objective outcome measures, classified these according to the pharmacopsychometric triangle and compared them qualitatively in terms of incremental information added to the clinical study question. The data reviewed here from primarily depression and schizophrenia intervention studies show that results from PRO measures and CRO measures generally point in the same direction. There was a relative lack of PRO measures on functioning and medication side effects compared with PRO measures on symptom burden and health-related quality of life.
Conclusion: PROs and CROs supplement each other and at most times support identical study conclusions. Future studies would benefit from a more systematic approach toward use of PROs and a clearer rationale of how to weigh and report the results in comparison with CROs.
Keywords: clinical intervention; patient involvement; patient-centered care; performance measures; routine outcome measures.
© The Author(s) 2021. Published by Oxford University Press on behalf of International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Patnode CD, Perdue LA, Rossom RC, Rushkin MC, Redmond N, Thomas RG, Lin JS. Patnode CD, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Feb. Report No.: 19-05257-EF-1. Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Feb. Report No.: 19-05257-EF-1. PMID: 32129963 Free Books & Documents. Review.
Lin JS, O'Connor E, Rossom RC, Perdue LA, Burda BU, Thompson M, Eckstrom E. Lin JS, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Nov. Report No.: 14-05198-EF-1. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Nov. Report No.: 14-05198-EF-1. PMID: 24354019 Free Books & Documents. Review.
Osborne SR, Alston LV, Bolton KA, Whelan J, Reeve E, Wong Shee A, Browne J, Walker T, Versace VL, Allender S, Nichols M, Backholer K, Goodwin N, Lewis S, Dalton H, Prael G, Curtin M, Brooks R, Verdon S, Crockett J, Hodgins G, Walsh S, Lyle DM, Thompson SC, Browne LJ, Knight S, Pit SW, Jones M, Gillam MH, Leach MJ, Gonzalez-Chica DA, Muyambi K, Eshetie T, Tran K, May E, Lieschke G, Parker V, Smith A, Hayes C, Dunlop AJ, Rajappa H, White R, Oakley P, Holliday S. Osborne SR, et al. Med J Aust. 2020 Dec;213 Suppl 11:S3-S32.e1. doi: 10.5694/mja2.50881. Med J Aust. 2020. PMID: 33314144
Andersen JC. Andersen JC. J Athl Train. 2011 Jan-Feb;46(1):99-102. doi: 10.4085/1062-6050-46.1.99. J Athl Train. 2011. PMID: 21214357 Free PMC article.
Allen D, Gillen E, Rixson L. Allen D, et al. JBI Libr Syst Rev. 2009;7(3):80-129. doi: 10.11124/01938924-200907030-00001. JBI Libr Syst Rev. 2009. PMID: 27820426
Kølbæk P, Mors O, Correll CU, Østergaard SD. Kølbæk P, et al. Schizophrenia (Heidelb). 2023 Dec 16;9(1):88. doi: 10.1038/s41537-023-00420-6. Schizophrenia (Heidelb). 2023. PMID: 38104195 Free PMC article.
Vita A, Barlati S, Deste G, Nibbio G, Penn DL, Pinkham AE, McIntyre RS, Harvey PD. Vita A, et al. Psychol Med. 2023 Dec;53(16):7943-7952. doi: 10.1017/S0033291723002106. Epub 2023 Jul 31. Psychol Med. 2023. PMID: 37522514 Free PMC article.
Addington J, Chao A, Braun A, Miller M, Farris MS. Addington J, et al. Schizophr Bull Open. 2023 Feb 23;4(1):sgad006. doi: 10.1093/schizbullopen/sgad006. eCollection 2023 Jan. Schizophr Bull Open. 2023. PMID: 37025755 Free PMC article. Review.
Pinho LG, Lopes MJ, Correia T, Sampaio F, Arco HRD, Mendes A, Marques MDC, Fonseca C. Pinho LG, et al. J Pers Med. 2021 Aug 10;11(8):776. doi: 10.3390/jpm11080776. J Pers Med. 2021. PMID: 34442420 Free PMC article. Review.